Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften

Stülke, Jörg, Prof. Dr.

Professor of Microbiology

  • 1990: Diploma (Biology), Ernst-Moritz-Arndt-Universität Greifswald
  • 1994: Dissertation (Dr. rer. nat.), Ernst-Moritz-Arndt-Universität Greifswald
  • 1994-1996: Postdoctoral Fellow at the Institut Pasteur, Paris
  • 1996-2003: Group leader at the Chair of Microbiology, University Erlangen-Nürnberg
  • 2000: Habilitation (Microbiology), University Erlangen-Nürnberg
  • since 2003: Professor of General Microbiology, Head of the Department of General Microbiology at the Institute of Microbiology and Genetics, University of Göttingen



Major Research Interests
Our group studies the regulation of metabolism in the pathogenic bacterium Mycoplasma pneumoniae and the model organism Bacillus subtilis. We are following global (“post-genomic”) and gene-specific approaches. In Mycoplasma pneumoniae, we study the regulation of gene expression in this pathogenic bacterium and its relation to pathogenicity. This is highly interesting because this bacterium is an important cause of pneumonia. Moreover, M. pneumoniae is one of the organisms with the smallest genetic equipment that is capable of independent life. Understanding M. pneumoniae means understanding life! Specifically, we are analysing protein phosphorylation and mechanisms of transcription regulation in M. pneumoniae. We have shown, that protein phosphorylation of is of key importance for pathogenicity of M. pneumoniae. Metabolism in Bacillus subtilis is studied by transcriptomics, metabolome and fluxome analyses. Our specific interests are focussed on two key pathways: glycolysis and glutamate biosynthesis, the decisive link between carbon and nitrogen metabolism. The regulation of glycolysis is studied at the level of a controlled protein-RNA interaction. Regulation through RNA has become widely recognized in the past few years. Our studies revealed that glycolytic enzymes themselves are part of a protein complex that is required for mRNA processing and degradation. Finally, we are interested in systems biology approaches to the analysis of B. subtilis and develop web interfaces for the functional annotation.

Homepage Department/Research Group
http://genmibio.uni-goettingen.de/

ORCID: 0000-0001-5881-5390